牛肝硫氰酸酶的共价结构和三级结构。
The covalent and tertiary structure of bovine liver rhodanese.
作者信息
Ploegman J H, Drent G, Kalk K H, Hol W G, Heinrikson R L, Keim P, Weng L, Russell J
出版信息
Nature. 1978 May 11;273(5658):124-9. doi: 10.1038/273124a0.
DOI:10.1038/273124a0
PMID:643076
Abstract
Bovine liver rhodanese is a single polypeptide of 293 amino acids in which the halves of the molecule assume analogous tertiary structures in the absence of substantial sequence homology. The sulphur atom transferred during catalysis is bound in persulphide linkage to Cys-247. Substrate binding seems to involve Arg-186 and Lys-249.
摘要
牛肝硫氰酸酶是一种由293个氨基酸组成的单条多肽链，在缺乏大量序列同源性的情况下，该分子的两半呈现出相似的三级结构。催化过程中转移的硫原子以过硫化物键与半胱氨酸-247结合。底物结合似乎涉及精氨酸-186和赖氨酸-249。
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