Watanabe S, Reddy K R, Jeffers L, Dickinson G M, O'Connell M, Schiff E R
Hepatology. 1984 Jul-Aug;4(4):628-32. doi: 10.1002/hep.1840040410.
Characteristic pathological alterations of the liver in chimpanzees inoculated with non-A, non-B hepatitis sera have been described, but no corresponding findings have been reported in humans. Electron microscopic studies of the liver biopsy specimens of two homosexual patients with acquired immune deficiency syndrome, one without hepatitis (Patient 1) and one with chronic active hepatitis in remission (Patient 2), revealed the cytoplasmic tubular structures which are characteristic of chimpanzee non-A, non-B hepatitis. A cluster of 23 nm double-shelled particles was also seen in the cytoplasm of a hepatocyte in patient 1 who had received a blood transfusion 8 days before the biopsy. These particles were smaller than the Dane particles, Epstein-Barr virus, cytomegalovirus or herpes simplex virus, and different from hepatitis A virus particles; the antibodies to all of which are found in high concentration in acquired immune deficiency syndrome patients. These observations may reflect the morphologic findings for non-A, non-B hepatitis infection in humans.
已描述了接种非甲非乙型肝炎血清的黑猩猩肝脏的特征性病理改变，但人类中尚未报告相应的发现。对两名患有获得性免疫缺陷综合征的同性恋患者的肝脏活检标本进行电子显微镜研究，其中一名无肝炎（患者1），另一名慢性活动性肝炎处于缓解期（患者2），发现了黑猩猩非甲非乙型肝炎特有的细胞质管状结构。在活检前8天接受输血的患者1的肝细胞细胞质中也发现了一簇23纳米的双壳颗粒。这些颗粒比丹氏颗粒、爱泼斯坦-巴尔病毒、巨细胞病毒或单纯疱疹病毒小，且与甲型肝炎病毒颗粒不同；在获得性免疫缺陷综合征患者中均发现针对所有这些病毒的抗体浓度很高。这些观察结果可能反映了人类非甲非乙型肝炎感染的形态学发现。
