Bonino F, Baldi M, Demartini A
Division of Gastroenterology, San Giovanni Battista Molinette Hospital, Torino, Italy.
Eur J Clin Microbiol Infect Dis. 1988 Jun;7(3):327-36. doi: 10.1007/BF01962332.
A review is given on the current knowledge of the hepatitis delta virus (HDV), the only hepatotropic non-A and non-B (NANB) virus characterized, although the infection it causes requires infection with hepatitis B virus (HBV). Studies in chimpanzees have provided the most data now available on the putative NANB agents. Histologic and electron microscopic changes occurring in HDV and NANB hepatitis have been shown to be comparable, and some biologic, epidemiologic and clinical features are similar. However, the lack of cross-protection between NANB and HDV hepatitis in cross-challenge transmission experiments and the lack of hybridization between HDV-RNA and nucleic acids from NANB material indicate that HDV and the putative NANB agents are minimally, if at all, related.
本文综述了丁型肝炎病毒（HDV）的现有知识，HDV是唯一已明确的嗜肝非甲非乙型（NANB）病毒，尽管其引起的感染需要同时感染乙型肝炎病毒（HBV）。对黑猩猩的研究提供了目前关于假定的NANB病原体的最多数据。已表明HDV肝炎和NANB肝炎中出现的组织学和电子显微镜变化具有可比性，并且一些生物学、流行病学和临床特征相似。然而，在交叉攻击传播实验中NANB肝炎和HDV肝炎之间缺乏交叉保护，以及HDV-RNA与NANB物质的核酸之间缺乏杂交，表明HDV与假定的NANB病原体即使有关联也是微乎其微的。
