Bystedt H, Heimdahl A, Nord C E
Int J Oral Surg. 1984 Jun;13(3):200-5. doi: 10.1016/s0300-9785(84)80004-6.
10 patients with odontogenic cysts were given 500 mg tinidazole orally every 12 h for infection prophylaxis before cystectomy. The administration started 48 h before operation and lasted for 7 days. Samples for assay of tinidazole were collected from blood plasma and cystic fluid during surgery. Saliva samples for microbiological studies of the normal flora were obtained before, during and after the antibiotic administration period. Mean concentrations of tinidazole in plasma and cystic fluid were 10.7 mg/l and 10.0 mg/l, respectively. The anaerobic flora was suppressed in all patients and two patients were colonized with enterobacteria, and two with fungi. No anaerobic bacterial strains resistant to tinidazole emerged during the treatment period. It is concluded that tinidazole can be administered prophylactically 48 h before oral surgery, in order to obtain maximal tissue concentration, without risk of the emergence of resistant bacterial strains or severe ecological disturbances of the oral microflora.
10例牙源性囊肿患者在囊肿切除术前，每12小时口服500毫克替硝唑以预防感染。给药在手术前48小时开始，持续7天。手术期间从血浆和囊液中采集替硝唑测定样本。在抗生素给药期之前、期间和之后获取唾液样本，用于正常菌群的微生物学研究。血浆和囊液中替硝唑的平均浓度分别为10.7毫克/升和10.0毫克/升。所有患者的厌氧菌均受到抑制，2例患者被肠杆菌定植，2例被真菌定植。治疗期间未出现对替硝唑耐药的厌氧菌株。结论是，替硝唑可在口腔手术前48小时预防性给药，以获得最大组织浓度，而不会出现耐药菌株或口腔微生物群严重生态紊乱的风险。
