Viitanen J, Auvinen O, Tunturi T
Chemotherapy. 1983;29(1):13-7. doi: 10.1159/000238167.
Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromatography. The weight-standardized tinidazole concentrations in the serum, muscle tissue and appendix in all specimens were higher than the minimal inhibitory concentration (2 micrograms/g) of Bacteroides fragilis. The tinidazole concentrations of adipose tissue exceeded the limit of 1 microgram/g in all samples. The concentrations were high already in the 10-min patient group. The authors consider a tinidazole infusion started half an hour before the operation at a dose of 10 mg/kg of the patient's body weight to be a reliable procedure if the objective is to acquire a sufficient tissue concentration of tinidazole (2 micrograms/g) to prevent infection complications caused by anaerobic bacteria.
在36例成年患者进行阑尾切除术之前，静脉输注500毫克替硝唑。手术中，在输液停止后10、20、30、60或120分钟采集组织样本（血液、阑尾根部、肌肉、脂肪）。通过液相色谱法测定替硝唑浓度。所有标本中血清、肌肉组织和阑尾中按体重标准化的替硝唑浓度均高于脆弱拟杆菌的最低抑菌浓度（2微克/克）。所有样本中脂肪组织的替硝唑浓度均超过1微克/克的限值。在10分钟的患者组中浓度就已经很高了。作者认为，如果目标是获得足够的替硝唑组织浓度（2微克/克）以预防厌氧菌引起的感染并发症，那么在手术前半小时开始以10毫克/千克患者体重的剂量输注替硝唑是一种可靠的方法。
