Lundström I M, Anneroth G B, Holmberg K
Int J Oral Surg. 1984 Jun;13(3):226-38. doi: 10.1016/s0300-9785(84)80008-3.
The presence of yeasts in oral lichen planus (OLP) lesions was studied in cultivations from 41 OLP patients and by histological examination in 39 of these cases. The histological features of OLP were also recorded. The cultivation results were compared with those of a randomly selected, age- and sex-matched control group without mucosal changes. The extent of growth was recorded as "sparse" (1-10 colonies), "model-rate" (11-40 colonies), or "heavy" (greater than 40 colonies). Yeasts were found to be present on cultures or histologic sections from a total of 19 OLP patients (46%). "Moderate-heavy" growth was obtained in 29% of the OLP cases but in only 7% of the control group. Candida albicans accounted for over 80% of the yeasts. The histological examination revealed only 3 cases of invasive fungal growth. Regarding the criteria of OLP, hyperortho- or hyperparakeratosis and a band-shaped subepithelial infiltration of lymphocytes were present in all specimens, basilar liquefaction degeneration in 87% and an eosinophilic zone in 77%. Local treatment with amphotericin B (Fungizone) in 18 OLP patients with positive findings resulted in subjective relief of symptoms in 89% of the patients. Clinical improvement was seen in 94%. The presence of Candida was significantly correlated to low secretion rate in unstimulated saliva.
对41例口腔扁平苔藓（OLP）患者病变组织进行培养，并对其中39例进行组织学检查，以研究酵母在OLP病变中的存在情况。同时记录OLP的组织学特征。将培养结果与随机选取的、年龄和性别匹配且无黏膜改变的对照组进行比较。生长程度记录为“稀疏”（1 - 10个菌落）、“中等程度”（11 - 40个菌落）或“大量”（超过40个菌落）。共19例OLP患者（46%）的培养物或组织切片中发现有酵母。29%的OLP病例出现“中等 - 大量”生长，而对照组仅为7%。白色念珠菌占酵母的80%以上。组织学检查仅发现3例侵袭性真菌生长。关于OLP的标准，所有标本均存在过度正角化或过度不全角化以及带状的上皮下淋巴细胞浸润，87%有基底细胞液化变性，77%有嗜酸性带。对18例检查结果呈阳性的OLP患者用两性霉素B（Fungizone）进行局部治疗，89%的患者症状主观缓解，94%有临床改善。念珠菌的存在与非刺激性唾液低分泌率显著相关。
