Hedde J P, Fiegler W, Schulz S, Christe W, Felix R
Rofo. 1984 Aug;141(2):212-9. doi: 10.1055/s-2008-1053119.
In 26 patients the regional cerebral blood flow was measured using 123I-isopropyl-amphetamine. The measurement was performed with a dynamic single photon emission tomograph. In 16 patients we compared the findings with the results of the tomographic 133Xe-Clearance. Both methods seem to be suitable for the measurement of the effective perfusion and gave similar results. In the case of the tomographic 133Xe-clearance we need a more specialized technical equipment whereas the permanent costs are lower and the performance less complicated. Besides the applicability of this method is more universal. On the contrary the use of 123I-isopropyl-amphetamine makes a higher resolution possible depending on the available equipment and does not need an ability to cooperation of the patient. With the presently disposable radionuclides the hope was not yet adequately accomplished, to get a tomographic in-vivo-information of cerebral metabolic and receptor-functions by means of SPECT.
对26例患者使用123I-异丙基安非他明测量局部脑血流量。测量通过动态单光子发射断层扫描仪进行。在16例患者中，我们将这些结果与断层扫描133Xe清除率的结果进行了比较。两种方法似乎都适用于有效灌注的测量，且结果相似。对于断层扫描133Xe清除率，我们需要更专业的技术设备，但其长期成本较低且操作不太复杂。此外，这种方法的适用性更广泛。相反，根据现有设备，使用123I-异丙基安非他明可以实现更高的分辨率，并且不需要患者配合。对于目前使用的一次性放射性核素，通过单光子发射计算机断层扫描（SPECT）获得脑代谢和受体功能的断层体内信息的希望尚未充分实现。
