Crimi N, Palermo F, Sorace R, Gibellino F, Mistretta A
Respiration. 1984;45(3):262-4. doi: 10.1159/000194627.
The nifedipine effect was studied in 8 extrinsic asthmatic subjects with exercise-induced asthma. Before the exercise the patients received, in a randomized double-blind manner, either 20 mg nifedipine, sublingually or sodium cromoglycate by inhalation on 2 separate days. Nifedipine and sodium cromoglycate in all patients inhibited the exercise fall in FEV1. No differences were found between the two drugs. Nifedipine is a potent antagonist of calcium ion influx in smooth muscle and secretory cells, and these studies suggest that it may inhibit release of mast cell mediators and reduce bronchial smooth muscle contractility in asthma.
在8名患有运动诱发性哮喘的外源性哮喘患者中研究了硝苯地平的效果。在运动前，患者以随机双盲方式，在两个不同的日子分别接受20毫克舌下含服的硝苯地平或吸入色甘酸钠。所有患者中，硝苯地平和色甘酸钠均抑制了运动引起的第一秒用力呼气量（FEV1）下降。两种药物之间未发现差异。硝苯地平是平滑肌和分泌细胞中钙离子内流的强效拮抗剂，这些研究表明它可能抑制肥大细胞介质的释放并降低哮喘中支气管平滑肌的收缩性。
