Patel K R
Clin Allergy. 1981 Sep;11(5):429-32. doi: 10.1111/j.1365-2222.1981.tb01615.x.
The effect of nifedipine was studied in fifteen patients with exercise-induced asthma. Nifedipine inhibited the exercise-induced fall in FEV1 almost completely in four patients, offered partial protection in a further nine patients and had no effect in the remaining two patients. It is suggested that mediator release which is dependent on free calcium ions may play an important role in exercise-induced asthma and calcium antagonists may inhibit post-exercise bronchoconstriction by their blocking effect on calcium channels of the mast cells.
对15例运动诱发性哮喘患者进行了硝苯地平疗效的研究。硝苯地平几乎完全抑制了4例患者运动诱发的第一秒用力呼气量（FEV1）下降，对另外9例患者提供了部分保护作用，而对其余2例患者无效。提示依赖游离钙离子的介质释放可能在运动诱发性哮喘中起重要作用，钙拮抗剂可能通过对肥大细胞钙通道的阻断作用抑制运动后支气管收缩。
