人类口腔癌组织中的环氧化酶和脂氧合酶途径。
The cyclo-oxygenase and lipoxygenase pathways in human oral cancer tissue.
作者信息
Porteder H, Matejka M, Ulrich W, Sinzinger H
出版信息
J Maxillofac Surg. 1984 Aug;12(4):145-7. doi: 10.1016/s0301-0503(84)80234-9.
PMID:6432928
Abstract
This paper reports on the synthesis of prostaglandins in oral squamous epithelial carcinomas. Using radio-thin-layer chromatography, we observed the conversion of 14C-labelled arachidonic acid into the prostaglandins PGE2, PGF2 alpha, PGI2 and PGD2. We also observed an approximately equal production of hydroxy fatty acids. The role of the above-mentioned substances in the growth of malignant tumours and the process of metastasis is discussed.
摘要
本文报道了口腔鳞状上皮癌中前列腺素的合成情况。利用放射性薄层层析法，我们观察到14C标记的花生四烯酸转化为前列腺素PGE2、PGF2α、PGI2和PGD2。我们还观察到羟基脂肪酸的生成量大致相等。文中讨论了上述物质在恶性肿瘤生长和转移过程中的作用。
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