Cochard P, Paulin D
J Neurosci. 1984 Aug;4(8):2080-94. doi: 10.1523/JNEUROSCI.04-08-02080.1984.
The appearance of neurofilaments (NFs) and vimentin (Vim) in the nervous system of the mouse embryo was documented using immunohistochemical techniques. The three NF protein subunits appear early and simultaneously in central and peripheral neurons at 9 to 10 days of gestation. The onset of NF expression is concomitant with axon elongation and correlates extremely well with neurofibrillar differentiation and, in the case of autonomic ganglia, with the expression of adrenergic neurotransmitter properties. In the central and peripheral nervous system, NF expression is preceded by that of Vim, and both types of intermediate filaments coexist within the same cell for a short period of time.
利用免疫组织化学技术记录了小鼠胚胎神经系统中神经丝（NFs）和波形蛋白（Vim）的出现情况。三种NF蛋白亚基在妊娠9至10天时早期同时出现在中枢和外周神经元中。NF表达的开始与轴突伸长同时发生，并且与神经原纤维分化密切相关，在自主神经节中，与肾上腺素能神经递质特性的表达相关。在中枢和外周神经系统中，Vim的表达先于NF的表达，并且两种类型的中间丝在同一细胞内短时间共存。
