Zafra F, Aragon M C, Valdivieso F, Gimenez C
Neurochem Res. 1984 May;9(5):695-707. doi: 10.1007/BF00964516.
Transport of beta-alanine has been demonstrated in membrane vesicles isolated from rat brain, using artificially imposed ion gradients as the sole energy source. The uptake of beta-alanine is strictly dependent on the presence of Na+ and Cl- in the medium, and the process can be driven either by an Na+ gradient (out greater than in) or by a Cl- gradient (out greater than in) when the other essential ion is present. The process is stimulated by a membrane potential (negative inside) as demonstrated by the effect of ionophore valinomycin and anions with different permeabilities. beta-Alanine uptake is inhibited by the presence of GABA.
利用人工施加的离子梯度作为唯一能量来源，已在从大鼠脑部分离出的膜囊泡中证实了β-丙氨酸的转运。β-丙氨酸的摄取严格依赖于培养基中Na⁺和Cl⁻的存在，当存在另一种必需离子时，该过程可由Na⁺梯度（外向内高）或Cl⁻梯度（外向内高）驱动。如离子载体缬氨霉素和具有不同通透性的阴离子的作用所示，该过程受到膜电位（内侧为负）的刺激。GABA的存在会抑制β-丙氨酸的摄取。
