Smith B T
Pediatr Res. 1978 Jan;12(1):12-4. doi: 10.1203/00006450-197801000-00004.
Injection of 11-ketoprogesterone into fetal rats at day 17 of gestation reduced the pulmonary C-11 activation index (an indicator of net gain or loss of glucocorticoid activity) as measured at day 21 (P less than 0.001) and resulted in elevated levels of the inactive hormone 11-dehydrocorticosterone (P less than 0.001), but unchanged corticosterone levels. Adrenal weight was significantly increased (P less than 0.001). 11-Ketoprogesterone-injected fetuses had considerably larger lungs (P less than 0.001) with reduced saturated phosphatidylcholine content (P less than 0.001).
在妊娠第17天给胎鼠注射11-酮孕酮，会降低在第21天测量的肺C-11激活指数（糖皮质激素活性净增减的指标）（P<0.001），并导致无活性激素11-脱氢皮质酮水平升高（P<0.001），但皮质酮水平不变。肾上腺重量显著增加（P<0.001）。注射11-酮孕酮的胎鼠肺部明显更大（P<0.001），饱和磷脂酰胆碱含量降低（P<0.001）。
