Iannello D, Bonina L, Delfino D, Berlinghieri M C, Gismondo M R, Mastroeni P
Ann Immunol (Paris). 1984 May-Jun;135C(3):345-52. doi: 10.1016/s0769-2625(84)80964-2.
In consideration of the well documented influence of normal microbial flora on the level of activation of macrophages, we evaluated the effects of oral administration of bacteria on rats with depressed macrophage functions. An oral, killed polyvalent vaccine (Diplococcus pneumoniae types I, II and III, Streptococcus haemolyticus, Staphylococcus aureus and Haemophilus influenzae), the live lyophilized Streptococcus faecium and spores of Bacillus subtilis, respectively, were administered orally to immuno-depressed rats. Results demonstrate the restoration of phagocytosis, intracellular killing and the chemotactic activity of macrophages. These experimental observations suggest that bacterial flora associated with mucosae can influence the level of activation of peritoneal macrophages.
鉴于正常微生物群对巨噬细胞激活水平的影响已有充分文献记载，我们评估了口服细菌对巨噬细胞功能低下的大鼠的影响。分别向免疫抑制的大鼠口服一种口服灭活多价疫苗（I、II和III型肺炎双球菌、溶血性链球菌、金黄色葡萄球菌和流感嗜血杆菌）、活冻干粪肠球菌和枯草芽孢杆菌孢子。结果表明巨噬细胞的吞噬作用、细胞内杀伤作用和趋化活性得到恢复。这些实验观察结果表明，与黏膜相关的细菌菌群可影响腹膜巨噬细胞的激活水平。
