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大鼠肺谷胱甘肽S-转移酶。存在两种不同类型的22000道尔顿亚基的证据。

Rat lung glutathione S-transferases. Evidence for two distinct types of 22000-Mr subunits.

作者信息

Singh S V, Partridge C A, Awasthi Y C

出版信息

Biochem J. 1984 Aug 1;221(3):609-15. doi: 10.1042/bj2210609.

DOI:10.1042/bj2210609
PMID:6433888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144088/
Abstract

Two immunologically distinct types of 22000-Mr subunits are present in rat lung glutathione S-transferases. One of these subunits is probably similar to Ya subunits of rat liver glutathione S-transferases, whereas the other subunit Ya' is immunologically distinct. Glutathione S-transferase II (pI7.2) of rat lung is a heterodimer (YaYa') of these subunits, and glutathione S-transferase VI (pI4.8) of rat lung is a homodimer of Ya' subunits. On hybridization in vitro of the subunits of glutathione S-transferase II of rat lung three active dimers having pI values 9.4, 7.2 and 4.8 are obtained. Immunological properties and substrate specificities indicate that the hybridized enzymes having pI7.2 and 4.8 correspond to glutathione S-transferases II and VI of rat lung respectively.

摘要

大鼠肺谷胱甘肽S-转移酶中存在两种免疫性质不同的22000道尔顿亚基。其中一种亚基可能与大鼠肝脏谷胱甘肽S-转移酶的Ya亚基相似，而另一种亚基Ya'在免疫上是不同的。大鼠肺的谷胱甘肽S-转移酶II（pI7.2）是这些亚基的异二聚体（YaYa'），大鼠肺的谷胱甘肽S-转移酶VI（pI4.8）是Ya'亚基的同二聚体。大鼠肺谷胱甘肽S-转移酶II的亚基在体外杂交时，可得到三种活性二聚体，其pI值分别为9.4、7.2和4.8。免疫性质和底物特异性表明，pI7.2和4.8的杂交酶分别对应于大鼠肺的谷胱甘肽S-转移酶II和VI。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed21/1144088/944d75440ebc/biochemj00322-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed21/1144088/488aa646ab56/biochemj00322-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed21/1144088/944d75440ebc/biochemj00322-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed21/1144088/488aa646ab56/biochemj00322-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed21/1144088/944d75440ebc/biochemj00322-0059-a.jpg

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引用本文的文献

1
Two immunologically distinct Yc-type subunits are present in rat lung glutathione S-transferases.大鼠肺谷胱甘肽S-转移酶中存在两种免疫上不同的Yc型亚基。
Biochem J. 1984 Nov 15;224(1):335-8. doi: 10.1042/bj2240335.
2
Immunochemical localization of glutathione S-transferases in rat lung.
Lung. 1984;162(5):305-13. doi: 10.1007/BF02715661.
3
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本文引用的文献

1
An enzyme from rat liver catalysing conjugations with glutathione.一种来自大鼠肝脏的可催化与谷胱甘肽结合反应的酶。
Biochem J. 1961 Jun;79(3):516-24. doi: 10.1042/bj0790516.
2
Diffusion-in-gel methods for immunological analysis.用于免疫分析的凝胶扩散法。
Prog Allergy. 1958;5:1-78.
3
Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver.人肝脏谷胱甘肽S-转移酶阴离子和阳离子形式之间的相互关系。
Biochem J. 1985 Dec 15;232(3):781-90. doi: 10.1042/bj2320781.
4
Acidic glutathione S-transferases of rat testis.大鼠睾丸的酸性谷胱甘肽S-转移酶
Biochem J. 1985 Aug 15;230(1):125-32. doi: 10.1042/bj2300125.
5
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Biochem J. 1985 Jan 15;225(2):375-82. doi: 10.1042/bj2250375.
6
Use of immuno-blot techniques to discriminate between the glutathione S-transferase Yf, Yk, Ya, Yn/Yb and Yc subunits and to study their distribution in extrahepatic tissues. Evidence for three immunochemically distinct groups of transferase in the rat.使用免疫印迹技术区分谷胱甘肽S-转移酶Yf、Yk、Ya、Yn/Yb和Yc亚基，并研究它们在肝外组织中的分布。大鼠体内存在三种免疫化学性质不同的转移酶组的证据。
Biochem J. 1986 Feb 1;233(3):779-88. doi: 10.1042/bj2330779.
7
Glutathione S-transferases of mouse lung. Selective binding of benzo[a]pyrene metabolites by the subunits which are preferentially induced by t-butylated hydroxyanisole.小鼠肺中的谷胱甘肽S-转移酶。叔丁基化羟基茴香醚优先诱导的亚基对苯并[a]芘代谢物的选择性结合。
Biochem J. 1987 Apr 15;243(2):351-8. doi: 10.1042/bj2430351.
8
Purification and characterization of glutathione S-transferases of human kidney.人肾谷胱甘肽S-转移酶的纯化与特性分析
Biochem J. 1987 Aug 15;246(1):179-86. doi: 10.1042/bj2460179.
9
Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein.Wistar大鼠中雄甾酮UDP-葡萄糖醛酸基转移酶活性的遗传缺陷是由于酶蛋白的缺失。
Biochem J. 1986 Feb 15;234(1):139-44. doi: 10.1042/bj2340139.
10
Single-step purification and h.p.l.c. analysis of glutathione transferase 8-8 in rat tissues.大鼠组织中谷胱甘肽转移酶8-8的一步纯化及高效液相色谱分析
Biochem J. 1989 Jun 15;260(3):785-8. doi: 10.1042/bj2600785.
Biochem J. 1980 Oct 1;191(1):1-10. doi: 10.1042/bj1910001.
4
Tissue distribution and subunit structures of the multiple forms of glutathione S-transferase in the rat.大鼠体内谷胱甘肽S-转移酶多种形式的组织分布及亚基结构
Biochem J. 1981 Jan 1;193(1):367-70. doi: 10.1042/bj1930367.
5
Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol.四种具有不同催化特异性的蛋白质亚基的二元组合解释了大鼠肝细胞溶质中六种基本谷胱甘肽S-转移酶之间的关系。
J Biol Chem. 1982 Sep 10;257(17):9909-12.
6
A study of the structures of the YaYa and YaYc glutathione S-transferases from rat liver cytosol. Evidence that the Ya monomer is responsible for lithocholate-binding activity.大鼠肝细胞溶质中YaYa和YaYc谷胱甘肽S-转移酶结构的研究。Ya单体负责石胆酸结合活性的证据。
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7
Studies on the subunit composition of rat liver glutathione S-transferases.大鼠肝脏谷胱甘肽S-转移酶亚基组成的研究。
J Biol Chem. 1983 Sep 25;258(18):11321-5.
8
Structural, functional and hybridization studies of the glutathione S-transferases of rat liver.大鼠肝脏谷胱甘肽S-转移酶的结构、功能及杂交研究
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9
Immunological relationships among subunits of glutathione S-transferases A, AA, B and ligandin and hybrid formation between AA and ligandin by guanidine hydrochloride.谷胱甘肽S-转移酶A、AA、B亚基与配体蛋白之间的免疫学关系以及盐酸胍诱导的AA与配体蛋白之间的杂交形成
Biochem Biophys Res Commun. 1981 Dec 15;103(3):943-50. doi: 10.1016/0006-291x(81)90901-3.
10
Evidence that the Yb subunits of hepatic glutathione transferases represent two different but related families of polypeptides.肝脏谷胱甘肽转移酶的Yb亚基代表两个不同但相关的多肽家族的证据。
Eur J Biochem. 1983 Dec 1;137(1-2):125-9. doi: 10.1111/j.1432-1033.1983.tb07805.x.