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慢性淋巴细胞白血病的临床分期与免疫学发现

Clinical stage and immunological findings in chronic lymphocytic leukemia.

作者信息

Baldini L, Mozzana R, Cesana B, Cortellezzi A, Neri A, Radaelli F

出版信息

Boll Ist Sieroter Milan. 1984 Mar;63(1):50-6.

PMID:6433940
Abstract

The total and T-lymphocyte counts, different types of lymphocytic surface immunoglobulins and levels of serum immunoglobulins were studied in 112 consecutive patients with chronic lymphocytic leukemia in order to investigate possible correlations between the immunological picture and the different stages according to the staging criteria recently proposed by Binet et al. Patients were also subdivided according to the form of their disease, "indolent" or "active", and correlations with the immunological picture investigated. The total lymphocyte count showed a significantly increasing trend through the three different stage (p less than 0.01), and it was higher in the "active" than in the "indolent" disease (p less than 0.01). Also the number of T-lymphocytes increased in the "active" forms (p less than 0.01). No statistically significant correlations were observed between the different surface immunoglobulin subclasses and the clinical pattern. As regard the various classes of serum immunoglobulins, the number of patients, with a reduction of at least one of the classes tended to increase with worsening of the clinical stage.

摘要

为了根据比内等人最近提出的分期标准研究免疫状况与不同阶段之间可能存在的相关性,我们对112例连续性慢性淋巴细胞白血病患者的淋巴细胞总数、T淋巴细胞计数、不同类型淋巴细胞表面免疫球蛋白以及血清免疫球蛋白水平进行了研究。患者还根据其疾病形式分为“惰性”或“活动性”,并研究了与免疫状况的相关性。淋巴细胞总数在三个不同阶段呈显著上升趋势(p<0.01),且“活动性”疾病患者的淋巴细胞总数高于“惰性”疾病患者(p<0.01)。“活动性”疾病形式的T淋巴细胞数量也增加(p<0.01)。未观察到不同表面免疫球蛋白亚类与临床模式之间存在统计学显著相关性。至于各类血清免疫球蛋白,至少有一类减少的患者数量倾向于随着临床分期的恶化而增加。

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