Paterson M E, Peel K R, Joslin C A
Br Med J (Clin Res Ed). 1984 Oct 6;289(6449):896-8. doi: 10.1136/bmj.289.6449.896.
The smear histories of 312 women with cancer of the cervix have been determined. Eighty nine women had had at least one negative smear reported in the 10 years before a diagnosis of cancer and 14 had had more than one negative smear. Fifty six of the 89 women had had a negative smear in the three years preceding the diagnosis of cancer. The highest number of negative smears (61) reported was among the 115 women aged under 45. Fifty eight slides reported as negative were submitted to independent review; 13 were subsequently reported as negative, 11 as unsatisfactory, and 34 as abnormal. These findings may in part explain why in this region there has been a disappointing reduction in the incidence of clinically invasive cervix cancer, and our findings may also apply elsewhere. Nevertheless, the confirmed negative smears chiefly occurred within three years of clinical cancer, particularly in the younger women, and this finding suggests that these women may have a short preinvasive phase.
已确定312名宫颈癌女性的涂片检查史。89名女性在癌症诊断前10年内至少有一次涂片检查结果为阴性，其中14名女性有不止一次阴性涂片检查结果。89名女性中有56名在癌症诊断前三年有过阴性涂片检查结果。报告的阴性涂片检查结果数量最多（61次）的是115名45岁以下的女性。58份报告为阴性的涂片被送去进行独立复查；随后13份被报告为阴性，11份为不满意，34份为异常。这些发现可能部分解释了为什么在该地区临床浸润性宫颈癌的发病率下降令人失望，我们的发现可能也适用于其他地方。然而，确诊的阴性涂片主要发生在临床癌症出现的三年内，尤其是在年轻女性中，这一发现表明这些女性的癌前阶段可能较短。
