Johannesson G, Alm P, Biber B, Lennander O, Werner O
Acta Anaesthesiol Scand. 1984 Aug;28(4):381-4. doi: 10.1111/j.1399-6576.1984.tb02081.x.
The anaesthetic properties of a halothane-in-fat solution given either as a single i.v. dose or as a continuous i.v. infusion were investigated in rats. 0.3 ml of a 5% solution of halothane in fat emulsion was injected i.v. into 15 awake rats. At the end of the 30 s injection, all rats had collapsed from the upright position and showed no response to a firmly applied tail clamp. Breathing usually became shallow and irregular just after injection. Two rats died. In the surviving rats, movement in response to clamping of the tail reappeared after some 30 s (range 15-90 s). The rats regained the upright position after about 100 s, and appeared fully awake about 3 min (range 2-5 min) after injection. Surviving rats behaved normally after the experiment, and gained in weight. They were killed 1-29 days later. The lungs, kidneys, heart, brain and liver had a normal macroscopic and microscopic appearance. In a second set of experiments (n = 9), a 10% solution of halothane was continuously infused i.v. (3.75 microliters min-1). The anaesthetic depth, as well as the mean arterial pressure, heart rate, respiratory rate and arterial PCO2 and PO2 were similar to values observed during inhalation of halothane in air at an inspired concentration of 1.1%. By doubling the infusion rate, MAP was reduced by 23%. It was easy to adjust anaethestic depth by changing the infusion rate and recovery was fast.
研究了以单次静脉注射剂量或连续静脉输注方式给予大鼠氟烷 - 脂肪溶液的麻醉特性。将0.3 ml含5%氟烷的脂肪乳剂溶液静脉注射到15只清醒大鼠体内。在30秒注射结束时，所有大鼠均从直立姿势倒下，对用力夹住尾巴无反应。注射后呼吸通常立即变得浅而不规则。两只大鼠死亡。在存活的大鼠中，大约30秒（范围15 - 90秒）后对夹尾刺激的运动反应重新出现。大鼠在约100秒后恢复直立姿势，注射后约3分钟（范围2 - 5分钟）似乎完全清醒。存活的大鼠在实验后行为正常，体重增加。它们在1 - 29天后被处死。肺、肾、心脏、脑和肝脏的宏观和微观外观均正常。在第二组实验（n = 9）中，以3.75微升/分钟的速度静脉连续输注10%的氟烷溶液。麻醉深度以及平均动脉压、心率、呼吸频率、动脉血二氧化碳分压和氧分压与吸入1.1%吸入浓度的氟烷 - 空气混合气时观察到的值相似。将输注速度加倍后，平均动脉压降低了23%。通过改变输注速度很容易调节麻醉深度，且恢复迅速。
