Hiki Y, Kokubo T, Horii A, Yokouchi S, Satoh M, Kuwao S, Shigematsu H, Kobayashi Y
Department of Medicine, School of Nursing and Medicine, Kitasato University, Sagamihara, Japan.
Acta Pathol Jpn. 1993 Sep;43(9):522-8.
A patient is described with severe IgA nephropathy associated with psoriatic arthritis, idiopathic interstitial pneumonia and brain hemorrhage that developed serially over one and a half years. The histological findings of the renal biopsy showed severe endo- and extracapillary proliferative glomerulonephritis. Massive IgA deposits were observed by immunofluorescence not only in the mesangium but also along the capillary walls. Electron microscopy revealed abundant electron-dense deposits in the mesangial and subendothelial areas. The overlapping or coexistence of these conditions has rarely been reported.
