Yoo T J, Yazawa Y, Floyd R, Tomoda K
Ann Otol Rhinol Laryngol Suppl. 1984 Sep-Oct;113:1-2. doi: 10.1177/00034894840930s501.
Rats were immunized with native type II bovine collagen to induce autoimmune inner ear disease, and the antibody activity in the inner ear fluid was measured. Antibody activity against type II collagen was detected in the perilymph at about 10% to 20% of serum level. Thus, the presence of antibody against type II collagen in inner ear fluid may imply an immune injury mechanism in inner ear diseases.
用天然II型牛胶原蛋白免疫大鼠以诱导自身免疫性内耳疾病，并测量内耳液中的抗体活性。在大约10%至20%血清水平的外淋巴中检测到针对II型胶原蛋白的抗体活性。因此，内耳液中存在针对II型胶原蛋白的抗体可能意味着内耳疾病中的免疫损伤机制。
