Yoo T J, Tomoda K, Hernandez A D
Ann Otol Rhinol Laryngol Suppl. 1984 Sep-Oct;113:3-5. doi: 10.1177/00034894840930s502.
Guinea pigs immunized with type II collagen developed histologic changes resembling those observed in patients with sensorineural hearing loss associated with connective tissue diseases. The histologic changes observed in the inner ears of these guinea pigs included spiral ganglion cell degeneration, atrophied organ of Corti, atrophy of stria vascularis, and mild extension of Reissner's membrane. These pathologic changes were accompanied by both humoral and cell-mediated immune responses directed against type II collagen--a collagen found in the subepithelial layer of the endolymphatic duct and spiral ligament. These findings suggest that an immune response directed against type II collagen can induce inner ear lesions.
用II型胶原蛋白免疫的豚鼠出现了类似于在与结缔组织疾病相关的感音神经性听力损失患者中观察到的组织学变化。在这些豚鼠内耳中观察到的组织学变化包括螺旋神经节细胞变性、柯蒂氏器萎缩、血管纹萎缩以及Reissner膜轻度伸展。这些病理变化伴随着针对II型胶原蛋白的体液免疫和细胞介导免疫反应，II型胶原蛋白是在内淋巴管和螺旋韧带的上皮下层中发现的一种胶原蛋白。这些发现表明，针对II型胶原蛋白的免疫反应可诱发内耳病变。
