Harris J P
Otolaryngol Head Neck Surg. 1983 Feb;91(1):18-32. doi: 10.1177/019459988309100105.
The relationship of the inner ear to host immunity and the immunoresponsiveness of the inner ear to antigen challenge were investigated. A radioimmunoassay was used to quantitate antibody titers to keyhole-limpet hemocyanin generated in the serum, perilymph, and CSF of guinea pigs following systemic or inner ear immunizations. The results of these experiments demonstrate (1) the blood-labyrinth barrier is analogous to the blood-brain barrier with respect to immunoglobulin equilibrium, (2) the inner ear is capable of responding to antigen challenge, and (3) the inner ear is an effective route for systemic immunization.
研究了内耳与宿主免疫的关系以及内耳对抗原刺激的免疫反应性。采用放射免疫分析法对豚鼠经全身或内耳免疫后血清、外淋巴和脑脊液中产生的针对钥孔戚血蓝蛋白的抗体滴度进行定量。这些实验结果表明：（1）血迷路屏障在免疫球蛋白平衡方面类似于血脑屏障；（2）内耳能够对抗原刺激作出反应；（3）内耳是全身免疫的有效途径。
