脲基青霉素单独及与阿米卡星和三种头孢菌素抗生素联合使用时的体外活性。
In vitro activities of ureidopenicillins alone and in combination with amikacin and three cephalosporin antibiotics.
作者信息
Moody J A, Peterson L R, Gerding D N
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):256-9. doi: 10.1128/AAC.26.2.256.
The MIC and MBC activity of mezlocillin alone and in combination with two concentrations of ceftizoxime, moxalactam, and amikacin and a single concentration of cefoxitin was studied in a broth microdilution partial checkerboard against 472 strains of aerobic gram-negative and gram-positive bacteria. Azlocillin was tested alone and in the same combinations against Pseudomonas aeruginosa. Of the gram-negative bacilli tested, 38% were gentamicin resistant. Antagonism (less than or equal to a fourfold ureidopenicillin MIC increase) was observed frequently with combinations of ureidopenicillins plus cefoxitin and sporadically with ureidopenicillins plus ceftizoxime or moxalactam. Partial synergism (less than or equal to a fourfold ureidopenicillin MIC decrease) was evident with both combinations of ureidopenicillins plus amikacin and ureidopenicillins plus ceftizoxime or moxalactam, the percentage being dependent upon the individual species and combinations.
采用肉汤微量稀释棋盘法，研究了美洛西林单独使用以及与两种浓度的头孢唑肟、拉氧头孢和丁胺卡那霉素以及单一浓度的头孢西丁联合使用时，对472株需氧革兰氏阴性菌和革兰氏阳性菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）活性。对铜绿假单胞菌单独测试了阿洛西林以及与相同组合的联合使用情况。在所测试的革兰氏阴性杆菌中，38%对庆大霉素耐药。脲基青霉素与头孢西丁联合使用时，经常观察到拮抗作用（脲基青霉素MIC增加小于或等于四倍），脲基青霉素与头孢唑肟或拉氧头孢联合使用时偶尔观察到拮抗作用。脲基青霉素与丁胺卡那霉素联合使用以及脲基青霉素与头孢唑肟或拉氧头孢联合使用时，均明显出现部分协同作用（脲基青霉素MIC降低小于或等于四倍），其百分比取决于个别菌种和组合。
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