肠球菌杀伤缺陷：作用于细胞壁的抗菌药物的共同特性。
Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall.
作者信息
Krogstad D J, Pargwette A R
出版信息
Antimicrob Agents Chemother. 1980 Jun;17(6):965-8. doi: 10.1128/AAC.17.6.965.
Abstract
We tested the ability of antimicrobial agents that act on the cell wall to kill enterococci and found defective killing (a minimal bactericidal concentration/minimal inhibitory concentration ratio of greater than or equal to 32) with both beta-lactams (penicillin G and cephalothin) and non-beta-lactams (vancomycin, cycloserine, and bacitracin). Our results indicate that the resistance of enterococci to antimicrobial killing spans the spectrum of agents known to inhibit cell wall synthesis and suggest that the mechanism responsible for enterococcal resistance to killing by these drugs may be a defective autolytic enzyme system.
摘要
我们测试了作用于细胞壁的抗菌剂杀灭肠球菌的能力，发现β-内酰胺类抗生素（青霉素G和头孢噻吩）以及非β-内酰胺类抗生素（万古霉素、环丝氨酸和杆菌肽）均存在杀菌缺陷（最低杀菌浓度/最低抑菌浓度比值大于或等于32）。我们的结果表明，肠球菌对抗菌剂杀灭作用的耐药性涵盖了已知抑制细胞壁合成的各类药物，这提示肠球菌对这些药物产生耐药性的机制可能是自溶酶系统存在缺陷。
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