• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall.肠球菌杀伤缺陷：作用于细胞壁的抗菌药物的共同特性。
Antimicrob Agents Chemother. 1980 Jun;17(6):965-8. doi: 10.1128/AAC.17.6.965.
2
Studies on antibiotic syngerism against enterococci. II. Effect of various antibiotics on the uptake of 14 C-labeled streptomycin by enterococci.抗肠球菌抗生素协同作用的研究。II. 多种抗生素对肠球菌摄取14C标记链霉素的影响。
J Clin Invest. 1971 Dec;50(12):2580-4. doi: 10.1172/JCI106758.
3
Antimicrobial tolerance in group C and group G streptococci.
J Antimicrob Chemother. 1984 Apr;13(4):389-92. doi: 10.1093/jac/13.4.389.
4
In vitro response to bactericidal activity of cell wall-active antibiotics does not support the general opinion that enterococci are naturally tolerant to these antibiotics.细胞壁活性抗生素杀菌活性的体外反应并不支持肠球菌对这些抗生素天然耐药的普遍观点。
Antimicrob Agents Chemother. 1990 Aug;34(8):1518-22. doi: 10.1128/AAC.34.8.1518.
5
Antibiotic-induced lysis of enterococci.抗生素诱导的肠球菌裂解
J Clin Invest. 1981 Sep;68(3):639-45. doi: 10.1172/jci110298.
6
Comparative killing rates of fluoroquinolones and cell wall-active agents.氟喹诺酮类药物与细胞壁活性药物的比较杀菌率。
Antimicrob Agents Chemother. 2000 May;44(5):1377-80. doi: 10.1128/AAC.44.5.1377-1380.2000.
7
Temperature effects on minimum inhibitory and bactericidal concentrations of cell wall antibiotics in Streptococcus faecalis.温度对粪肠球菌中细胞壁抗生素的最低抑菌浓度和杀菌浓度的影响。
Antimicrob Agents Chemother. 1977 Aug;12(2):281-3. doi: 10.1128/AAC.12.2.281.
8
Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci.N-甲酰亚胺硫霉素对肠球菌缺乏体内和体外杀菌活性。
Antimicrob Agents Chemother. 1982 Sep;22(3):448-52. doi: 10.1128/AAC.22.3.448.
9
[The differentiation and sensitivity of enterococci to chemotherapeutics in urinary tract infections].
Zentralbl Bakteriol Orig. 1968;209(1):18-25.
10
Studies on antibiotic synergism against enterococci. I. Bacteriologic studies.抗肠球菌抗生素协同作用的研究。I. 细菌学研究。
J Lab Clin Med. 1971 May;77(5):821-8.

引用本文的文献

1
Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection.氨苄西林联合头孢托罗培南治疗粪肠球菌感染性心内膜炎和血流感染的疗效评估。
Sci Rep. 2025 Jan 28;15(1):3519. doi: 10.1038/s41598-025-87512-8.
2
Bacterial persisters: molecular mechanisms and therapeutic development.细菌持久态：分子机制与治疗开发。
Signal Transduct Target Ther. 2024 Jul 17;9(1):174. doi: 10.1038/s41392-024-01866-5.
3
Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.适应逆境：肠球菌中应激耐受与发病机制的交织。
Microbiol Mol Biol Rev. 2019 Jul 17;83(3). doi: 10.1128/MMBR.00008-19. Print 2019 Aug 21.
4
Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance.肠球菌属粪肠球菌全基因组转录应答泰利霉素的分析揭示 CroRS 是抗菌药物耐受的必需调控因子。
mSphere. 2019 May 8;4(3):e00228-19. doi: 10.1128/mSphere.00228-19.
5
Thymidylate Limitation Potentiates Cephalosporin Activity toward Enterococci via an Exopolysaccharide-Based Mechanism.胸苷酸限制通过基于胞外多糖的机制增强头孢菌素对肠球菌的活性。
ACS Chem Biol. 2016 Jun 17;11(6):1561-8. doi: 10.1021/acschembio.5b01041. Epub 2016 Mar 23.
6
Vancomycin-resistant enterococcal infections: epidemiology, clinical manifestations, and optimal management.耐万古霉素肠球菌感染：流行病学、临床表现及最佳管理
Infect Drug Resist. 2015 Jul 24;8:217-30. doi: 10.2147/IDR.S54125. eCollection 2015.
7
Intrinsic and acquired resistance mechanisms in enterococcus.肠球菌固有和获得性耐药机制。
Virulence. 2012 Aug 15;3(5):421-33. doi: 10.4161/viru.21282.
8
Pilot study of ampicillin-ceftriaxone combination for treatment of orthopedic infections due to Enterococcus faecalis.氨苄西林-头孢曲松联合治疗粪肠球菌所致骨科感染的初步研究。
Antimicrob Agents Chemother. 2009 Oct;53(10):4305-10. doi: 10.1128/AAC.00444-09. Epub 2009 Aug 10.
9
Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2.自溶素AtlA对阿莫西林针对粪肠球菌JH2-2杀菌活性的作用。
Antimicrob Agents Chemother. 2009 Apr;53(4):1667-9. doi: 10.1128/AAC.00692-08. Epub 2009 Feb 2.
10
Issues in the Management of Endocarditis Caused by Resistant Gram-positive Organisms.耐革兰氏阳性菌引起的心内膜炎的管理问题
Curr Infect Dis Rep. 2004 Aug;6(4):283-291. doi: 10.1007/s11908-004-0049-7.

本文引用的文献

1
The Combined Action of Penicillin with Streptomycin or Chloromycetin on Enterococci in Vitro.青霉素与链霉素或氯霉素对肠球菌的体外联合作用
Science. 1950 Mar 10;111(2880):254-6. doi: 10.1126/science.111.2880.254.
2
Use of autoclaved extracts of hemolytic streptococci for serological grouping.使用溶血性链球菌的高压灭菌提取物进行血清学分型。
Stanford Med Bull. 1955 May;13(2):290-1.
3
The identity of streptococcal group D antigen with teichoic acid.D群链球菌抗原与磷壁酸的一致性。
J Gen Microbiol. 1963 May;31:231-9. doi: 10.1099/00221287-31-2-231.
4
Susceptibility of group D streptococcus (enterococcus) to 21 antibiotics in vitro, with special reference to species differences.D组链球菌（肠球菌）对21种抗生素的体外敏感性，特别提及种间差异。
Am J Med Sci. 1969 Dec;258(6):416-30. doi: 10.1097/00000441-196912000-00006.
5
Endocarditis due to group D streptococci. Comparison of disease caused by streptococcus bovis with that produced by the enterococci.D组链球菌所致的心内膜炎。牛链球菌引起的疾病与肠球菌引起的疾病的比较。
Am J Med. 1974 Aug;57(2):239-50. doi: 10.1016/0002-9343(74)90448-3.
6
Antibiotic susceptibility of Streptococcus bovis and other group D streptococci causing endocarditis.牛链球菌及其他引起心内膜炎的D群链球菌的抗生素敏感性
Antimicrob Agents Chemother. 1974 Mar;5(3):228-33. doi: 10.1128/AAC.5.3.228.
7
In vitro activity of ampicillin or vancomycin combined with gentamicin or streptomycin against enterococci.氨苄西林或万古霉素联合庆大霉素或链霉素对肠球菌的体外活性
Antimicrob Agents Chemother. 1973 Oct;4(4):383-7. doi: 10.1128/AAC.4.4.383.
8
Recognition of group D streptococcal species of human origin by biochemical and physiological tests.通过生化和生理学测试识别源自人类的D组链球菌菌种。
Appl Microbiol. 1972 Jun;23(6):1131-9. doi: 10.1128/am.23.6.1131-1139.1972.
9
Penicillin and gentamicin therapy for enterococcal infections.用于肠球菌感染的青霉素和庆大霉素疗法。
JAMA. 1973 Feb 26;223(9):1030-2.
10
Nonenterococcal group-D streptococcal endocarditis caused by Streptococcus bovis.由牛链球菌引起的非肠球菌D群链球菌性心内膜炎。
Ann Intern Med. 1974 Nov;81(5):588-93. doi: 10.7326/0003-4819-81-5-588.

肠球菌杀伤缺陷：作用于细胞壁的抗菌药物的共同特性。

Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall.

作者信息

Krogstad D J, Pargwette A R

出版信息

Antimicrob Agents Chemother. 1980 Jun;17(6):965-8. doi: 10.1128/AAC.17.6.965.

DOI:10.1128/AAC.17.6.965
PMID:6902640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283912/
Abstract

We tested the ability of antimicrobial agents that act on the cell wall to kill enterococci and found defective killing (a minimal bactericidal concentration/minimal inhibitory concentration ratio of greater than or equal to 32) with both beta-lactams (penicillin G and cephalothin) and non-beta-lactams (vancomycin, cycloserine, and bacitracin). Our results indicate that the resistance of enterococci to antimicrobial killing spans the spectrum of agents known to inhibit cell wall synthesis and suggest that the mechanism responsible for enterococcal resistance to killing by these drugs may be a defective autolytic enzyme system.

摘要

我们测试了作用于细胞壁的抗菌剂杀灭肠球菌的能力，发现β-内酰胺类抗生素（青霉素G和头孢噻吩）以及非β-内酰胺类抗生素（万古霉素、环丝氨酸和杆菌肽）均存在杀菌缺陷（最低杀菌浓度/最低抑菌浓度比值大于或等于32）。我们的结果表明，肠球菌对抗菌剂杀灭作用的耐药性涵盖了已知抑制细胞壁合成的各类药物，这提示肠球菌对这些药物产生耐药性的机制可能是自溶酶系统存在缺陷。