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1
Complexity of poly(A+) and poly(A-) polysomal RNA in mouse liver and cultured mouse fibroblasts.小鼠肝脏和培养的小鼠成纤维细胞中多聚腺苷酸阳性（poly(A+)）和多聚腺苷酸阴性（poly(A-)）多核糖体RNA的复杂性
Nucleic Acids Res. 1978 Mar;5(3):697-712. doi: 10.1093/nar/5.3.697.
2
Comparison of complexity and diversity of polyadenylated polysomal and informosomal messenger ribonucleic acid from Chinese hamster cells.中国仓鼠细胞中多聚腺苷酸化多核糖体和信息体信使核糖核酸的复杂性与多样性比较
Biochemistry. 1979 Sep 18;18(19):4254-61. doi: 10.1021/bi00586a034.
3
Sequence complexity and abundance classes of nuclear and polysomal polyadenylated RNA in Neurospora crassa.粗糙脉孢菌中核和多核糖体多聚腺苷酸化RNA的序列复杂性和丰度类别
Biochim Biophys Acta. 1980 Mar 28;607(1):122-35. doi: 10.1016/0005-2787(80)90226-9.
4
Size distribution of rat liver nuclear RNA containing mRNA sequences.含有信使核糖核酸序列的大鼠肝脏核核糖核酸的大小分布
Eur J Biochem. 1977 Jul 1;77(1):153-64. doi: 10.1111/j.1432-1033.1977.tb11653.x.
5
Complexity and specificity of polysomal poly(A+) RNA in mouse tissues.小鼠组织中多聚核糖体多聚腺苷酸（A+）RNA的复杂性和特异性
Biochemistry. 1976 Jun 29;15(13):2823-9. doi: 10.1021/bi00658a019.
6
Sequence complexity of nuclear and polysomal RNA in leaves of the tobacco plant.烟草植株叶片中细胞核和多核糖体RNA的序列复杂性
Cell. 1978 May;14(1):123-31. doi: 10.1016/0092-8674(78)90307-0.
7
Frequency distribution of messenger sequences within polysomal mRNA and nuclear RNA from rat liver.大鼠肝脏多聚核糖体mRNA和核RNA中信使序列的频率分布。
Eur J Biochem. 1977 Jul 1;77(1):141-51. doi: 10.1111/j.1432-1033.1977.tb11652.x.
8
Complex population of nonpolyadenylated messenger RNA in mouse brain.小鼠脑中复杂的非聚腺苷酸化信使核糖核酸群体。
Cell. 1979 Dec;18(4):1341-9. doi: 10.1016/0092-8674(79)90244-7.
9
Membrane-bound ribosomes of myeloma cells. IV. mRNA complexity of free and membrane-bound polysomes.骨髓瘤细胞的膜结合核糖体。IV. 游离及膜结合多核糖体的mRNA复杂性
J Cell Biol. 1981 Jan;88(1):29-36. doi: 10.1083/jcb.88.1.29.
10
Complexity of nuclear and polysomal polyadenylated RNA in a pluripotent embryonal carcinoma cell line.多能胚胎癌细胞系中核和多核糖体聚腺苷酸化RNA的复杂性
Biochemistry. 1978 Jan 10;17(1):69-79. doi: 10.1021/bi00594a010.

引用本文的文献

1
Poly A- transcripts expressed in HeLa cells.在HeLa细胞中表达的聚腺苷酸（Poly A）转录本。
PLoS One. 2008 Jul 30;3(7):e2803. doi: 10.1371/journal.pone.0002803.
2
Changes in Wheat Leaf Polysomal Messenger RNA Populations during the Early Stages of Rust Infection: EFFECTS OF CHLORAMPHENICOL AND LINCOMYCIN ON CELL-FREE TRANSLATION BY POLYSOMES FROM HEALTHY AND INFECTED LEAVES.锈病感染早期小麦叶片多核糖体信使核糖核酸群体的变化：氯霉素和林可霉素对健康及感染叶片多核糖体无细胞翻译的影响
Plant Physiol. 1980 Sep;66(3):520-4. doi: 10.1104/pp.66.3.520.
3
Evidence for a complex class of nonadenylated mRNA in Drosophila.果蝇中一类复杂的非腺苷酸化mRNA的证据。
Genetics. 1980 Jul;95(3):673-91. doi: 10.1093/genetics/95.3.673.
4
Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts.大鼠脑稀有转录本对应DNA的克隆：转录及转录后调控的证据以及非聚腺苷酸化转录本的存在证据
Mol Cell Biol. 1984 Oct;4(10):2187-97. doi: 10.1128/mcb.4.10.2187-2197.1984.
5
The appearance of new polyadenylated nuclear RNA sequences during rat-liver regeneration.大鼠肝脏再生过程中新的聚腺苷酸化核RNA序列的出现。
Nucleic Acids Res. 1981 Apr 24;9(8):2021-35. doi: 10.1093/nar/9.8.2021.
6
Relative distribution of post-nuclear poly(A)-containing RNA abundance groups within the nuclear and post-nuclear polyadenylated and non-polyadenylated RNA populations of the lactating guinea-pig mammary gland.哺乳期豚鼠乳腺细胞核内及核后多聚腺苷酸化和非多聚腺苷酸化RNA群体中含核后多聚（A）RNA丰度组的相对分布。
Biochem J. 1980 Nov 15;192(2):489-98. doi: 10.1042/bj1920489.
7
Chinese hamster polyadenylated messenger ribonucleic acid: relationship to non-polyadenylated sequences and relative conservation during messenger ribonucleic acid processing.中国仓鼠多聚腺苷酸化信使核糖核酸：与非多聚腺苷酸化序列的关系以及在信使核糖核酸加工过程中的相对保守性。
Mol Cell Biol. 1981 Feb;1(2):188-98. doi: 10.1128/mcb.1.2.188-198.1981.
8
Structure and function of rat liver polysome populations. I. Complexity, frequency distribution, and degree of uniqueness of free and membrane-bound polysomal polyadenylate-containing RNA populations.大鼠肝脏多核糖体群体的结构与功能。I. 游离及膜结合多核糖体含聚腺苷酸RNA群体的复杂性、频率分布及独特程度。
J Cell Biol. 1981 Aug;90(2):495-506. doi: 10.1083/jcb.90.2.495.
9
Olfactory neuron-specific protein is translated from a large poly(A)+ mRNA.嗅觉神经元特异性蛋白由一种大的多聚腺苷酸（poly(A)+）mRNA翻译而来。
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5218-22. doi: 10.1073/pnas.82.15.5218.
10
Preferential expression of unique sequences adjacent to middle repetitive sequences in mouse cytoplasmic RNA.小鼠细胞质RNA中与中度重复序列相邻的独特序列的优先表达。
Nucleic Acids Res. 1979 Oct 10;7(3):751-64. doi: 10.1093/nar/7.3.751.

本文引用的文献

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IDENTITY OF DNA AND DIVERSITY OF MESSENGER RNA MOLECULES IN NORMAL MOUSE TISSUES.正常小鼠组织中DNA的同一性与信使RNA分子的多样性
Proc Natl Acad Sci U S A. 1964 Oct;52(4):915-22. doi: 10.1073/pnas.52.4.915.
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RNA transcription from nonrepetitive DNA in the mouse.小鼠中非重复DNA的RNA转录
Biochem Biophys Res Commun. 1971 Mar 5;42(5):850-6. doi: 10.1016/0006-291x(71)90508-0.
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On the lability of poly(A) sequences during extraction of messenger RNA from polyribosomes.关于从多核糖体中提取信使核糖核酸过程中多聚腺苷酸序列的不稳定性。
Biochim Biophys Acta. 1972 Mar 14;262(2):220-6. doi: 10.1016/0005-2787(72)90236-5.
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Transcription of nonrepeated DNA in mouse brain.小鼠大脑中非重复DNA的转录
Science. 1971 Jul 9;173(3992):158-61. doi: 10.1126/science.173.3992.158.
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Three abundance classes in HeLa cell messenger RNA.HeLa细胞信使核糖核酸中的三种丰度类别。
Nature. 1974 Jul 19;250(463):199-204. doi: 10.1038/250199a0.
6
Hybridization of ribonucleic acid with unique sequences of mouse deoxyribonucleic acid.核糖核酸与小鼠脱氧核糖核酸独特序列的杂交
Biochemistry. 1972 Feb 29;11(5):798-805. doi: 10.1021/bi00755a019.
7
Preparation of ribonuclease-free DNase I and -amylase.无核糖核酸酶的脱氧核糖核酸酶I及淀粉酶的制备
Anal Biochem. 1973 Apr;52(2):342-8. doi: 10.1016/0003-2697(73)90035-3.
8
Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function.所有信使核糖核酸分子（组蛋白信使核糖核酸除外）均含有聚腺苷酸序列以及聚腺苷酸具有核功能的证据。
J Mol Biol. 1972 Oct 28;71(1):21-30. doi: 10.1016/0022-2836(72)90397-x.
9
Co-existence of non-histone messenger RNA species lacking and containing polyadenylic acid in sea urchin embryos.海胆胚胎中缺乏和含有聚腺苷酸的非组蛋白信使RNA种类的共存。
J Mol Biol. 1974 Nov 5;89(3):435-54. doi: 10.1016/0022-2836(74)90474-4.
10
A measurement of the sequence complexity of polysomal messenger RNA in sea urchin embryos.对海胆胚胎中多聚核糖体信使核糖核酸序列复杂性的测量。
Cell. 1974 May;2(1):9-20. doi: 10.1016/0092-8674(74)90003-8.

小鼠肝脏和培养的小鼠成纤维细胞中多聚腺苷酸阳性（poly(A+)）和多聚腺苷酸阴性（poly(A-)）多核糖体RNA的复杂性

Complexity of poly(A+) and poly(A-) polysomal RNA in mouse liver and cultured mouse fibroblasts.

作者信息

Grady L J, North A B, Campbell W P

出版信息

Nucleic Acids Res. 1978 Mar;5(3):697-712. doi: 10.1093/nar/5.3.697.

DOI:10.1093/nar/5.3.697
PMID:643615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342017/
Abstract

RNA excess hybridization experiments were used to measure the complexity of nuclear RNA, poly(A+) mRNA, poly(A-) mRNA, and EDTA-released polysomal RNA sedimenting at less than 80 S in mouse liver and in cultured mouse cells. With both cell types, poly(A-) RNA was found to contain 30-40% of the sequence diversity of total mRNA. In the case of liver this represents 5,700 poly(A-) molecules and 8,600 poly(A+) molecules for a total of approximately 14,300 different mRNAs. Comparison of the complexity of mRNA with that of nuclear RNA revealed that in liver and in cultured cells, mRNA has only 10-20% of the sequence diversity present in nuclear RNA. This latter observation is consistent with existing data on mammalian cells from this and other laboratories.

摘要

RNA过量杂交实验用于测量小鼠肝脏和培养的小鼠细胞中，沉降系数小于80S的核RNA、多聚腺苷酸阳性（poly(A+)）mRNA、多聚腺苷酸阴性（poly(A-)）mRNA以及EDTA释放的多核糖体RNA的复杂度。在这两种细胞类型中，发现poly(A-) RNA包含总mRNA序列多样性的30%-40%。就肝脏而言，这代表5700个poly(A-)分子和8600个poly(A+)分子，总共约14300种不同的mRNA。将mRNA的复杂度与核RNA的复杂度进行比较，发现在肝脏和培养细胞中，mRNA仅具有核RNA中10%-20%的序列多样性。后一观察结果与本实验室和其他实验室关于哺乳动物细胞的现有数据一致。