West R J, Russell M A, Jarvis M J, Pizzey T, Kadam B
Psychopharmacology (Berl). 1984;84(1):141-2. doi: 10.1007/BF00432045.
Urinary adrenaline concentrations were measured in 17 subjects during 10 days of cigarette abstinence. Adrenaline concentrations dropped significantly in the first 3 days of cigarette withdrawal. This was followed by a significant rise. More subjects showed a U-shaped function of adrenaline over time than would be expected by chance. The evidence suggests that the drop in urinary adrenaline concentration following cigarette withdrawal does not merely constitute a return to a non-smoking state, but includes an element of rebound resulting from loss of a component of smoking, probably nicotine, to which adaptation has occurred.
在17名受试者戒烟10天期间测量了尿肾上腺素浓度。在戒烟的头3天，肾上腺素浓度显著下降。随后显著上升。与随机预期相比，更多受试者的肾上腺素随时间呈现出U形变化。有证据表明，戒烟后尿肾上腺素浓度下降不仅仅是恢复到非吸烟状态，还包括因失去已产生适应的吸烟成分（可能是尼古丁）而导致的反弹因素。
