West R, Schneider N
Psychology Department, Royal Holloway and Bedford New College, London University, Egham, Surrey, UK.
Psychopharmacology (Berl). 1988;94(4):566-8. doi: 10.1007/BF00212857.
Data are reported on the heart rates of nine smokers who underwent 5 weeks of abstinence. There was an initial fall of 9.1 beats per min from 79 to 69.9 beats per min on the 1st day, with no significant change thereafter. The average heart rates after 2, 3, 4 and 5 weeks were 69.1, 69.1, 71.7 and 69.9 beats per min, respectively. Heart rate after 5 weeks was still significantly below baseline. The results indicate that the drop in heart rate which occurs open smoking abstinence is either a permanent change, or if it is a temporary withdrawal effect lasts longer than 5 weeks. If it is a permanent change then it may not make sense to consider drop in heart rate as part of a withdrawal syndrome; it could merely reflect absence of nicotine's stimulant action.
报告了9名吸烟者在5周戒烟期间的心率数据。第一天心率从每分钟79次初始下降9.1次至每分钟69.9次，此后无显著变化。2周、3周、4周和5周后的平均心率分别为每分钟69.1次、69.1次、71.7次和69.9次。5周后的心率仍显著低于基线水平。结果表明，戒烟时出现的心率下降要么是永久性变化，要么如果是暂时的戒断效应，持续时间超过5周。如果是永久性变化，那么将心率下降视为戒断综合征的一部分可能没有意义；它可能仅仅反映了尼古丁刺激作用的缺失。
