West R J, Russell M A, Jarvis M J, Feyerabend C
Psychopharmacology (Berl). 1984;84(1):120-3. doi: 10.1007/BF00432039.
Twenty-six smokers took part in a study which examined subjective and physiological effects of switching to an ultra-low yielding cigarette (0.1 mg nicotine) for 10 days. Subjects were randomly assigned to one of two groups. One group continued smoking their usual brand while the other group switched to the low yielding cigarette. Subjective ratings and physiological measures were taken at baseline, then after 1, 3 and 10 days in the respective conditions. Plasma nicotine concentrations dropped by some 60% after switching. Although substantial, this drop was considerably less than the drop in nominal yield of the cigarettes (around 90%), indicating marked compensation on the part of these smokers. Switching to the low yielding cigarette was accompanied by a significant increase in hunger and a drop in heart rate. These effects typically occur following cigarette withdrawal. However, other common cigarette withdrawal symptoms, such as irritability, depression, and inability to concentrate, were not detected.
26名吸烟者参与了一项研究，该研究考察了改用超低尼古丁含量香烟（0.1毫克尼古丁）10天的主观和生理影响。受试者被随机分为两组。一组继续抽他们常用的香烟品牌，而另一组则改用低尼古丁含量香烟。在基线时进行主观评分和生理测量，然后在各自条件下1天、3天和10天后再次测量。改用后血浆尼古丁浓度下降了约60%。尽管降幅很大，但这一降幅远小于香烟标称尼古丁含量的降幅（约90%），表明这些吸烟者有明显的补偿行为。改用低尼古丁含量香烟伴随着饥饿感显著增加和心率下降。这些影响通常在戒烟后出现。然而，未检测到其他常见的戒烟症状，如易怒、抑郁和注意力不集中。
