Mutti A, Vescovi P P, Falzoi M, Arfini G, Valenti G, Franchini I
Scand J Work Environ Health. 1984 Aug;10(4):225-8. doi: 10.5271/sjweh.2340.
The serum levels of prolactin (PRL), human growth hormone (HGH), thyroid-stimulating hormone (TSH), and the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured in 30 females exposed to about 130 (range 65-300) ppm of styrene in the air and in 30 age-matched referents to show whether styrene exposure influences the dopaminergic tuberoinfundibular system (TIDA). The exposed subjects' serum levels of PRL were more than double the reference values and were significantly related to the urinary excretion of styrene metabolites, ie, to the sum of mandelic acid (MA) and phenylglyoxylic acid (PGA) in the "next-morning" urine spot sample. Such a relationship still proved to be statistically significant after the removal of the effects of age and duration of exposure with the method of partial correlation. The serum concentrations of HGH in the exposed workers were also higher than in the reference group. Though within the reference levels, the TSH values of the exposed subjects were significantly related to the urinary excretion of MA and PGA. These results are consistent with the dose-dependent depletion in tuberoinfundibular dopamine after experimental styrene exposure of rabbits.
对30名空气中苯乙烯暴露水平约为130（范围65 - 300）ppm的女性以及30名年龄匹配的对照者，测量了催乳素（PRL）、人生长激素（HGH）、促甲状腺激素（TSH）以及促性腺激素卵泡刺激素（FSH）和黄体生成素（LH）的血清水平，以研究苯乙烯暴露是否会影响多巴胺能结节漏斗系统（TIDA）。暴露组受试者的PRL血清水平是参考值的两倍多，且与苯乙烯代谢物的尿排泄量显著相关，即与“次日晨尿”样本中扁桃酸（MA）和苯乙醇酸（PGA）的总和显著相关。采用偏相关方法去除年龄和暴露持续时间的影响后，这种关系仍具有统计学意义。暴露组工人的HGH血清浓度也高于对照组。虽然在参考水平范围内，但暴露组受试者的TSH值与MA和PGA的尿排泄量显著相关。这些结果与实验性苯乙烯暴露后家兔结节漏斗多巴胺的剂量依赖性消耗一致。
