Cummings N P, Strunk R C
Ann Allergy. 1984 Nov;53(5):395-400.
Fifty-three children with moderately severe asthma were studied to determine the capacity of drugs to block exercise-induced bronchospasm (EIB). All 53 children demonstrated EIB (as defined by a 20% fall in FEV1 or 30% fall in FEF25-75) while receiving therapeutic theophylline (serum level 10-20 micrograms/ml). EIB was completely blocked in 47 children by an inhaled metaproterenol 10 minutes prior to exercise, in addition to the theophylline. In six children, EIB was only partially blocked when either metaproterenol or cromolyn was added to the theophylline, but was completely blocked when all three drugs were used. A small group of children may benefit from combination therapy for EIB.
对53名中度重症哮喘患儿进行了研究，以确定药物阻断运动诱发性支气管痉挛（EIB）的能力。所有53名患儿在接受治疗剂量的茶碱（血清水平为10 - 20微克/毫升）时均表现出EIB（定义为第一秒用力呼气量（FEV1）下降20%或呼气流量峰值（FEF25 - 75）下降30%）。除茶碱外，47名患儿在运动前10分钟吸入间羟异丙肾上腺素后，EIB被完全阻断。在6名患儿中，当在茶碱基础上加用间羟异丙肾上腺素或色甘酸钠时，EIB仅被部分阻断，但当三种药物联合使用时，EIB被完全阻断。一小部分患儿可能从EIB的联合治疗中获益。
