Rohr A S, Siegel S C, Katz R M, Rachelefsky G S, Spector S L, Lanier R
Ann Allergy. 1987 Aug;59(2):107-9.
Inhaled albuterol and cromolyn by spinhaler have both been shown to be effective in the treatment of exercise-induced bronchospasm. Eighty subjects with exercise-induced bronchospasm participated in a randomized parallel group study comparing albuterol (180 microgram) and cromolyn (20 mg) administered 15 minutes prior to a standardized treadmill challenge. The cromolyn group was restudied after 2 and 4 weeks of 4 times/day cromolyn therapy. The albuterol group was also studied at 2 and 4 weeks, but they only used their inhaler as needed between study visits. The mean maximum FEV1 drop post-exercise in the albuterol group improved from 33% (screening visit) to 6% (treatment day 1). The cromolyn group showed significantly less (P less than .01) improvement than the albuterol group (31% drop at the screening visit to 14% drop at treatment day 1). When 2 or 4 weeks of continuous cromolyn therapy was given in addition to a dosage 15 minutes prior to exercise, there was no significant difference compared with acute cromolyn administration alone. In summary, acute administration of albuterol was better prophylaxis for exercise-induced bronchospasm than acute or chronic cromolyn treatment.
吸入沙丁胺醇和通过旋转吸入器吸入色甘酸钠已被证明在治疗运动诱发性支气管痉挛方面均有效。80名患有运动诱发性支气管痉挛的受试者参与了一项随机平行组研究，比较在标准化跑步机挑战前15分钟给予沙丁胺醇（180微克）和色甘酸钠（20毫克）的效果。色甘酸钠组在每天4次使用色甘酸钠治疗2周和4周后再次接受研究。沙丁胺醇组也在2周和4周时进行研究，但他们在研究访视期间仅根据需要使用吸入器。沙丁胺醇组运动后FEV1的平均最大下降幅度从筛查访视时的33%改善至治疗第1天时的6%。色甘酸钠组的改善明显低于沙丁胺醇组（P小于0.01）（筛查访视时下降31%至治疗第1天时下降14%）。当在运动前15分钟给药剂量的基础上再给予2周或4周的持续色甘酸钠治疗时，与单独急性给予色甘酸钠相比没有显著差异。总之，对于运动诱发性支气管痉挛，急性给予沙丁胺醇比急性或慢性色甘酸钠治疗有更好的预防效果。
