大鼠亚急性苯蒸气中毒时外周血白细胞的酶变化
Enzymatic changes in peripheral blood leukocytes in rats in subacute benzene vapours poisoning.
作者信息
Moszczyński P, Starek A
出版信息
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):21-7.
The activity of acid phosphatase (AcP), its intracellular distribution in peripheral blood lymphocytes and the activity of lysosomal isoenzyme of acid phosphatase (AcPL) in serum of rats exposed to benzene vapour in the concentration 27 000 mg/m3 for 6 hours daily through 10 consecutive days were investigated. The statistically significant fall in the number of lymphocytes affecting AcP-positive and AcP-negative lymphocytes, reduction in the percentage of granular lymphocytes and increase in the percentage of granular-diffusive and diffusive lymphocytes were found. The increase in the activity of AcPL in serum was statistically insignificant. According to the authors opinion the phenomenon observed results from a damage to lymphocytic lysosomes by benzene.
研究了大鼠连续10天每天暴露于浓度为27000mg/m³的苯蒸气中6小时后，酸性磷酸酶（AcP）的活性、其在外周血淋巴细胞中的细胞内分布以及血清中酸性磷酸酶溶酶体同工酶（AcPL）的活性。发现影响AcP阳性和AcP阴性淋巴细胞的淋巴细胞数量有统计学意义的下降，颗粒淋巴细胞百分比降低，颗粒-弥散和弥散淋巴细胞百分比增加。血清中AcPL活性的增加无统计学意义。作者认为观察到的现象是苯对淋巴细胞溶酶体造成损伤的结果。
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