[Effect of mixture of nitric and chlorine oxides on lymphocyte acid phosphatase activity in rats].

In rats chronically exposed to the mixture of nitric (1.22 mg/m3) and chlorine (1.02 mg/m3) oxides acid phosphatase activity (AcP) in peripheral blood lymphocytes as well as its intracellular distribution, were studied using Barka and Anderson's cytochemical method. Depressive effects of these compounds upon lymphocytic system were found in form of lymphocytopenia and a decrease in AcP--negative lymphocytes percentage. Evaluation of intracellular AcP distribution indicated that the mixture of nitric and chlorine oxides intensified enzyme diffusion from lysosomal granules into cytoplasm. The authors believe that lymphocytopenia results from the reduction in B lymphocytes number. At the same time they consider the contribution of these changes to immune reactions of the organism.