Moszczyński P, Starek A
Med Pr. 1978;29(6):453-7.
In rats chronically exposed to the mixture of nitric (1.22 mg/m3) and chlorine (1.02 mg/m3) oxides acid phosphatase activity (AcP) in peripheral blood lymphocytes as well as its intracellular distribution, were studied using Barka and Anderson's cytochemical method. Depressive effects of these compounds upon lymphocytic system were found in form of lymphocytopenia and a decrease in AcP--negative lymphocytes percentage. Evaluation of intracellular AcP distribution indicated that the mixture of nitric and chlorine oxides intensified enzyme diffusion from lysosomal granules into cytoplasm. The authors believe that lymphocytopenia results from the reduction in B lymphocytes number. At the same time they consider the contribution of these changes to immune reactions of the organism.
在长期暴露于一氧化氮（1.22毫克/立方米）和二氧化氯（1.02毫克/立方米）混合物的大鼠中，采用巴尔卡和安德森的细胞化学方法研究了外周血淋巴细胞中的酸性磷酸酶活性（AcP）及其细胞内分布。发现这些化合物对淋巴细胞系统有抑制作用，表现为淋巴细胞减少和AcP阴性淋巴细胞百分比降低。细胞内AcP分布的评估表明，一氧化氮和二氧化氯的混合物增强了酶从溶酶体颗粒向细胞质的扩散。作者认为淋巴细胞减少是由于B淋巴细胞数量减少所致。同时，他们考虑了这些变化对机体免疫反应的影响。
