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大鼠亚急性苯蒸气中毒时外周血白细胞的酶变化。II. 中性粒细胞酶的活性

Enzymatic changes in peripheral blood leukocytes in rats in subacute benzene vapours poisoning. II. The activity of neutrophils enzymes.

作者信息

Starek A, Moszczyński P, Czarnobilski Z

出版信息

Pol J Pharmacol Pharm. 1978 Jul-Aug;30(4):483-7.

PMID:740549
Abstract

The activity of some enzymes of neutrophils in peripheral blood of rats in subacute benzene vapour poisoning (an exposure to the concentration of benzene vapour of 27.000 mg/m3, 6 hr daily for 10 consecutive days) was determined cytochemically. Increase in the activity of alkaline phosphatase and decrease in that of acid hydrolases: acid phosphatase, beta-glucuronidase and beta-glucosaminidase were found. The results obtained indicate destructive action of benzene on lysosomes of peripheral blood neutrophils.

摘要

采用细胞化学方法测定了亚急性苯蒸气中毒(暴露于浓度为27000毫克/立方米的苯蒸气中,每天6小时,连续10天)大鼠外周血中性粒细胞中某些酶的活性。发现碱性磷酸酶活性增加,酸性水解酶(酸性磷酸酶、β-葡萄糖醛酸酶和β-氨基葡萄糖苷酶)活性降低。所得结果表明苯对外周血中性粒细胞溶酶体具有破坏作用。

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