Scott M T, Goss-Sampson M
Clin Exp Immunol. 1984 Nov;58(2):372-9.
IgG2 was the predominant specific antibody isotype in mice chronically infected with Y strain Trypanosoma cruzi; IgG1 and IgG3 antibodies were absent or present only at very low levels. Isotype analyses of the acute phase of infection confirmed no early production of IgG1 or IgG3 and no failure in the switch from IgM to IgG. In vivo passive transfer studies of immune serum fractions showed protection to be associated only with the IgG2 isotype. A characteristic specific anti-T. cruzi IgG isotype profile (IgG1, IgG3, greater than IgG2, IgG4) was detected in a majority (39 of 50) of sera from Chagas' disease patients.
在慢性感染克氏锥虫Y株的小鼠中，IgG2是主要的特异性抗体亚型；IgG1和IgG3抗体缺失或仅以极低水平存在。感染急性期的亚型分析证实，没有早期产生IgG1或IgG3，也没有从IgM转换为IgG的失败情况。免疫血清组分的体内被动转移研究表明，保护作用仅与IgG2亚型相关。在大多数（50例中的39例）恰加斯病患者的血清中检测到一种特征性的特异性抗克氏锥虫IgG亚型谱（IgG1、IgG3大于IgG2、IgG4）。
