Korman D B, Krutova T V, Shamaev V I
Farmakol Toksikol. 1984 Sep-Oct;47(5):70-4.
The cytotoxic action of thiophosphamide on the cells of 16 human tumor xenografts (lung, breast, colon and stomach carcinomas) was studied. The tumor xenografts placed into diffusion chambers were implanted into intact mice. It was demonstrated that thiophosphamide inhibits the progress of cancer cells to mitosis, reduces the rate of DNA synthesis and accumulation of the cells in mitosis and S-phase. The most pronounced and lasting alterations in cell proliferation were recorded in breast cancer, less significant in carcinoma of the stomach. These findings correlate with the data on the clinical efficacy of thiophosphamide applied to the treatment of these tumors.
研究了硫代磷酰胺对16种人肿瘤异种移植瘤（肺癌、乳腺癌、结肠癌和胃癌）细胞的细胞毒性作用。将置于扩散室中的肿瘤异种移植瘤植入正常小鼠体内。结果表明，硫代磷酰胺可抑制癌细胞进入有丝分裂，降低DNA合成速率以及有丝分裂期和S期细胞的积累。在乳腺癌中观察到细胞增殖最明显且持久的变化，在胃癌中变化则不那么显著。这些发现与硫代磷酰胺用于治疗这些肿瘤的临床疗效数据相关。
