Shamaev V I, Krutova T V, D'iachkovskaia R F, Korman D B
Biull Eksp Biol Med. 1981 Jul;92(7):77-9.
A study was made of the effect of nitrosomethylurea (NMU), thiophosphamide and diazane on proliferative activity of human breast cancer cells cultured in diffusion chambers in vivo. NMU highly suppressed the proliferation of human breast cancer cells throughout the experiment. The maximum effect of diazane and thiophosphamide became apparent after 24 hours, while almost complete renewal of the proliferation was observed by the 72nd hour of culture. Diazane and NMU hold promise for clinical trials in human breast cancer.
研究了亚硝基甲基脲（NMU）、硫磷酰胺和重氮烷对体内在扩散小室中培养的人乳腺癌细胞增殖活性的影响。在整个实验过程中，NMU高度抑制人乳腺癌细胞的增殖。重氮烷和硫磷酰胺的最大作用在24小时后显现，而在培养72小时时观察到增殖几乎完全恢复。重氮烷和NMU有望用于人乳腺癌的临床试验。
