凝血因子 VIII 促凝抗原回收率是对凝血因子 VIII 浓缩剂输注的剂量相关反应。

Factor VIII procoagulant antigen recovery is a dose-related response to Factor VIII concentrate infusions.

作者信息

Taylor L, Ekert H, Dean F

出版信息

Haemostasis. 1984;14(4):296-301. doi: 10.1159/000215078.

Abstract

The recovery and initial half-disappearance rate of factor VIII procoagulant activity (VIIIC) and procoagulant antigen (VIIICAg) were studied in 9 haemophilia A patients following infusion of factor VIII concentrates to varying plasma VIIIC levels. While VIIIC recovery was independent of dose, the VIIICAg recovery varied in a dose-dependent fashion. The excess of VIIICAg relative to VIIIC found in the factor VIII concentrates (VIIICAg/VIIIC ratios of 1.9-3.1) was not observed in plasma samples taken after low level infusions (plasma VIIIC less than 1 U/ml) but a significant excess of VIIICAg was observed in higher level infusions. The VIIICAg recovery of post-infusion plasma was not increased by treatment with phospholipase C.

摘要

在9例甲型血友病患者中，静脉输注不同剂量的凝血因子VIII浓缩剂，使其血浆凝血因子VIII促凝活性（VIIIC）达到不同水平，然后研究VIIIC和促凝抗原（VIIICAg）的恢复情况以及最初的半衰期消失率。虽然VIIIC的恢复与剂量无关，但VIIICAg的恢复呈剂量依赖性变化。在低剂量输注后采集的血浆样本（血浆VIIIC低于1 U/ml）中未观察到凝血因子VIII浓缩剂中存在的VIIICAg相对于VIIIC的过量情况（VIIICAg/VIIIC比值为1.9 - 3.1），但在高剂量输注中观察到VIIICAg显著过量。用磷脂酶C处理后，输注后血浆的VIIICAg恢复并未增加。