Muller H P, van Tilburg N H, Bertina R M, Terwiel J P, Veltkamp J J
Clin Chim Acta. 1980 Oct 23;107(1-2):11-9. doi: 10.1016/0009-8981(80)90408-8.
An immunoradiometric assay of procoagulant factor VIII antigen was developed using a human antibody to the procoagulant activity of factor VIII (VIII:C). The assay measures specifically the antigen related to factor VIII procoagulant activity (VIIICAG) both in plasma and in serum. VIII:C and VIIICAG were measured in a group of healthy individuals and in a group of haemophilia A patients. In haemophilia A at least four groups can be recognised on the basis of the presence or absence of VIII:C and VIIICAG and the VIII:C/VIIICAG ratio.
利用针对凝血因子VIII促凝活性（VIII:C）的人源抗体，开发了一种促凝因子VIII抗原的免疫放射分析方法。该分析方法专门用于测定血浆和血清中与因子VIII促凝活性相关的抗原（VIIICAG）。对一组健康个体和一组甲型血友病患者测定了VIII:C和VIIICAG。在甲型血友病中，根据VIII:C和VIIICAG的有无以及VIII:C/VIIICAG比值，至少可识别出四组。
