在无法检测到IgA的常见可变型低丙种球蛋白血症患者中检测α1和α2重链恒定区基因。
Detection of alpha 1 and alpha 2 heavy-chain constant-region genes in common variable hypogammaglobulinaemia patients with undetectable IgA.
作者信息
Smith C I, Hammarström L
出版信息
Scand J Immunol. 1984 Oct;20(4):361-3. doi: 10.1111/j.1365-3083.1984.tb01014.x.
Abstract
Five patients with common variable hypogammaglobulinaemia with undetectable levels of IgA in serum and saliva were investigated for immunoglobulin structural gene defects. All five patients carried in their genome alpha 1 and alpha 2 genes as detected in Southern blotting analysis by means of a cloned C alpha gene probe.
摘要
对5例血清和唾液中IgA水平检测不到的常见变异型低丙种球蛋白血症患者进行了免疫球蛋白结构基因缺陷研究。通过克隆的Cα基因探针进行Southern印迹分析，发现所有5例患者的基因组中均携带α1和α2基因。
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