Becqué O, Bernard Y, Bassand J P, Hervé P, Maurat J P
Arch Mal Coeur Vaiss. 1984 Nov;77(12):1359-62.
Hypertrophic myocardiopathy with obstruction (HOMC) is a disease of unknown aetiology with a high familial incidence. This study was undertaken to determine its relationship to the HLA system, as proved in a number of other conditions. The clinical suspicion of HOMC was confirmed in all cases by echocardiography. In addition, 4 patients were also catheterised, confirming the presence of an intraventricular pressure gradient. One patient was investigated after surgery. None of the patients was hypertensive. In two cases, a positive family history of HOMC confirmed the hereditary nature of the condition. The HLA-A and B grouping was performed by the micro-lymphocytotoxic technique. The HLA-DRW was carried out with B lymphocytes separated either by column filtration or by rosetting on a Ficoll gradient. We did not find a statistically significant prevalence of any of the antigens tested on the A, B on DRW loci. Our results were compared with previously published data. They support the findings of Bloch et al. in a genetically comparable study population (HLA A and B only) but contradict those of Matsumori (oriental population). We were unable to demonstrate a liaison between antigens of the HLA system and HOMC. However, as was shown in our study, HLA grouping is valuable in familial forms of HOMC (mechanism of transmission, detection of clinically latent forms).
梗阻性肥厚型心肌病（HOMC）是一种病因不明、家族发病率高的疾病。本研究旨在确定其与HLA系统的关系，这在许多其他疾病中已得到证实。所有病例均通过超声心动图确诊为临床疑似的HOMC。此外，4例患者还进行了心导管检查，证实存在心室内压力梯度。1例患者在手术后接受了检查。所有患者均无高血压。2例患者有HOMC家族史阳性，证实了该病的遗传性。HLA - A和B分型采用微量淋巴细胞毒技术进行。HLA - DRW分型是用通过柱过滤或在Ficoll梯度上进行玫瑰花结分离的B淋巴细胞进行的。我们没有发现在A、B或DRW位点上所检测的任何抗原存在统计学上的显著流行率。我们的结果与先前发表的数据进行了比较。它们支持了Bloch等人在遗传上可比的研究人群（仅HLA - A和B）中的发现，但与Matsumori（东方人群）的结果相矛盾。我们无法证明HLA系统的抗原与HOMC之间存在关联。然而，正如我们的研究所表明的，HLA分型在家族性HOMC形式中具有重要价值（传播机制、临床潜伏形式的检测）。
