Bodem R, Zipperle S, Ho A, Lenhard V
Z Kardiol. 1982 Dec;71(12):820-3.
The etiology of hypertrophic cardiomyopathy with (HOCM) and without obstruction (HCM) is poorly understood. Controversial data have been published concerning the association of HLA-B-12-antigen with HOCM and HCM respectively. Further, HLA-D-antigen occurrence has been determined in few patients with HOCM or HCM. In 29 patients with HOCM, 38 patients with HCM, and matched healthy persons we determined the occurrence of HLA-A, B, C and DRW-antigen using the test of microcytotoxicity in lymphocytes. HLA-antigens occurred with similar frequency in patients with HOCM and HCM and in control subjects. 25% of the patients and 23% of the control subjects had HLA-B-12. Further, no difference was detected in the frequency of occurrence of HLA-antigens in patients with HOCM and in patients with HCM. The data support the view that HLA tissue typing is of no diagnostic value in identifying patients with HOCM or HCM.
梗阻性肥厚型心肌病（HOCM）和非梗阻性肥厚型心肌病（HCM）的病因尚不清楚。关于HLA - B - 12抗原分别与HOCM和HCM的关联，已有相互矛盾的数据发表。此外，仅对少数HOCM或HCM患者测定了HLA - D抗原的出现情况。我们采用淋巴细胞微细胞毒性试验，对29例HOCM患者、38例HCM患者及匹配的健康人测定了HLA - A、B、C和DRW抗原的出现情况。HLA抗原在HOCM患者、HCM患者及对照受试者中的出现频率相似。25%的患者和23%的对照受试者有HLA - B - 12。此外，未检测到HOCM患者和HCM患者中HLA抗原出现频率的差异。这些数据支持以下观点：HLA组织分型在识别HOCM或HCM患者方面没有诊断价值。
