Hiai H, Ardman B
Gan. 1984 Oct;75(10):905-11.
A small population of normal thymic lymphocytes, like the majority of thymic leukemia cells, formed cellular complexes with thymic epithelium-like stromal cells in pseudoemperipolesis. The properties of the complex-forming cells in preleukemic AKR thymus were analyzed after separation of the cells into subpopulations on the basis of cell size and surface antigen expression by using a fluorescence-activated cell sorter. Complex-forming ability was associated with large cells and the following phenotypes: high Thy-1.1, low brain associated theta antigen, high H-2Kk, high Lyt-1, high gp70 and Ia negativity. These properties coincide in general with those of blast cells in the subcapsular zone of the thymus, which have been shown to consist mostly of complex-forming cells. The possible significance of complex formation of normal and leukemic thymocytes with thymic stromal cells is discussed.
一小部分正常胸腺淋巴细胞，如同大多数胸腺白血病细胞一样，在假吞噬现象中与胸腺上皮样基质细胞形成细胞复合体。通过使用荧光激活细胞分选仪，根据细胞大小和表面抗原表达将细胞分为亚群后，对白血病前期AKR胸腺中形成复合体的细胞特性进行了分析。形成复合体的能力与大细胞以及以下表型相关：高Thy-1.1、低脑相关θ抗原、高H-2Kk、高Lyt-1、高gp70以及Ia阴性。这些特性总体上与胸腺被膜下区的母细胞特性相符，已表明这些母细胞主要由形成复合体的细胞组成。文中讨论了正常和白血病胸腺细胞与胸腺基质细胞形成复合体的可能意义。
