Celis E, Miller R W, Chang T W
Hum Immunol. 1984 Dec;11(4):229-37. doi: 10.1016/0198-8859(84)90062-4.
The secretion of gamma-interferon (IFN-gamma), Interleukin-2 (IL-2), and B cell growth factor (BCGF) by human T cell clones specific for hepatitis B surface antigen (HBsAg) was examined. Antigenic stimulation by HBsAg but not by influenza A virus resulted in IFN-gamma and BCGF synthesis by the T cell clones. No detectable amounts of IL-2 were obtained in the supernatants of any of the HBsAg-specific T cell clones when cultured in the presence or absence of antigen. IFN-gamma and BCGF were produced, even when cell proliferation was inhibited, suggesting that the secretion of these T cell factors occurred regardless of cell proliferation. The significance of the various factors in the immune response against hepatitis B virus infection is discussed.
对针对乙型肝炎表面抗原（HBsAg）的人T细胞克隆分泌γ-干扰素（IFN-γ）、白细胞介素-2（IL-2）和B细胞生长因子（BCGF）的情况进行了检测。HBsAg而非甲型流感病毒的抗原刺激导致T细胞克隆合成IFN-γ和BCGF。在有或无抗原存在的情况下培养时，任何HBsAg特异性T细胞克隆的上清液中均未检测到IL-2。即使细胞增殖受到抑制，仍会产生IFN-γ和BCGF，这表明这些T细胞因子的分泌与细胞增殖无关。讨论了各种因子在针对乙型肝炎病毒感染的免疫反应中的意义。
