Orton C G, Mondalek P M, Spicka J T, Herron D S, Andres L I
Int J Radiat Oncol Biol Phys. 1984 Dec;10(12):2191-9. doi: 10.1016/0360-3016(84)90223-2.
This paper reviews reasons cited for and against the use of lung corrections. It is suggested that all the reasons cited for not making corrections are no longer viable. A phantom has been designed to simulate the thorax region of a patient at both CT and radiotherapy radiation energies. With this phantom, lung correction factors for the calculation of tumor dose have been measured for a typical lung cancer treatment regimen, and these results are shown to compare favorably with correction factors computed by all the commonly employed correction algorithms. Some algorithms are better than others, and one of the best is the readily hand-calculable generalized power-law TAR method. It is shown that failure to correct for lung transmission can severely limit the integrity of many interinstitutional studies, especially cooperative clinical trials. It is concluded that lung corrections for the calculation of tumor doses in the thorax region should be gradually introduced over the next several years.
本文回顾了支持和反对进行肺部校正的各种理由。结果表明，所有那些反对进行校正的理由已不再成立。已设计出一种体模，可在CT和放射治疗辐射能量下模拟患者的胸部区域。利用该体模，针对一种典型的肺癌治疗方案测量了用于计算肿瘤剂量的肺部校正因子，结果表明这些结果与所有常用校正算法计算出的校正因子相比具有优势。有些算法比其他算法更好，其中最好的算法之一是易于手工计算的广义幂律组织空气比（TAR）方法。结果表明，不进行肺部透射校正会严重限制许多机构间研究的完整性，尤其是合作临床试验。得出的结论是，在未来几年应逐步引入用于胸部区域肿瘤剂量计算的肺部校正。
