肌萎缩侧索硬化症：促甲状腺激素释放激素的双盲交叉试验
Amyotrophic lateral sclerosis: a double-blind crossover trial of thyrotropin-releasing hormone.
作者信息
Imoto K, Saida K, Iwamura K, Saida T, Nishitani H
出版信息
J Neurol Neurosurg Psychiatry. 1984 Dec;47(12):1332-4. doi: 10.1136/jnnp.47.12.1332.
Abstract
A double-blind crossover trial was conducted of thyrotropin releasing hormone treatment in six patients with amyotrophic lateral sclerosis. Patients received 4 mg of thyrotropin releasing hormone intramuscularly daily during the two-week treatment period. Although three patients reported subjective improvement, objective evaluation failed to demonstrate therapeutic effectiveness of thyrotropin releasing hormone in this dosage.
摘要
对6例肌萎缩侧索硬化症患者进行了促甲状腺激素释放激素治疗的双盲交叉试验。在为期两周的治疗期间，患者每天接受4毫克促甲状腺激素释放激素肌肉注射。尽管有3例患者报告主观症状有所改善，但客观评估未能证明该剂量的促甲状腺激素释放激素具有治疗效果。
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