Klimek A, Szulc-Kuberska J, Czernielewska-Rutkowska I, Głuszcz-Zielińska A
Klinika Neurologii AM w Lodzi.
Neurol Neurochir Pol. 1988 May-Jun;22(3):206-10.
In view of earlier reports in the literature it was tried to use TRH (thyrotropin releasing hormone) in cases of amyotrophic lateral sclerosis. TRH was given during 3 weeks once daily intravenously in drip infusions in a 0.4 mg dose. For objectivization of the results the muscle power was assessed using a five-grade scale of Lovette. TRH effect on EMG was analysed also. It was found that in only 3 out of 14 patients with moderately progressed disease no improvement was achieved, while in 11 cases the improvement was from 10 to 20%. However, the improvement was transient, and TRH treatment failed to stop the progression of the disease.
鉴于文献中早期的报道，曾尝试在肌萎缩侧索硬化症患者中使用促甲状腺激素释放激素（TRH）。以0.4毫克的剂量，通过静脉滴注，每日一次，连续3周给予TRH。为了使结果客观化，使用洛维特五级量表评估肌肉力量。还分析了TRH对肌电图的影响。结果发现，在14例病情中度进展的患者中，只有3例未取得改善，而在11例患者中，改善幅度为10%至20%。然而，这种改善是短暂的，TRH治疗未能阻止疾病的进展。
