Gross D, Vartian V, Minami H, Chang H K, Zidulka A
Bull Eur Physiopathol Respir. 1984 Nov-Dec;20(6):507-11.
High frequency chest wall compression (HFCWC) was studied as a method of assisting ventilation in six spontaneously breathing anesthetized dogs. Under a constant level of anesthesia, the dogs became hypercapneic after airflow obstruction was created by metal beads inserted in the airways. HFCWC was achieved by a piston pump rapidly oscillating the pressure in a modified double blood pressure cuff wrapped around the lower thorax. Thirty minute periods of spontaneous ventilation were alternated with thirty minute periods of spontaneous breathing plus HFCWC at 3, 5 or 8 Hz. The superimposition of HFCWC to spontaneous ventilation resulted in little change in the PaO2. The PaCO2, however, was reduced in every case from a mean of 6.55 +/- 0.59 to 4.72 +/- 0.32 kPa at 3 Hz (p less than 0.05), 6.92 +/- 0.57 to 3.9 +/- 0.45 kPa at 5 Hz (p less than 0.01) and 7.10 +/- 0.65 to 4.56 +/- 0.59 kPa at 8 Hz (p less than 0.05). This occurred despite a decrease in spontaneous minute ventilation. We conclude that HFCWC can assist in elimination of CO2 in obstructed spontaneous breathing dogs with hypercapnea.
高频胸壁按压(HFCWC)作为一种辅助通气的方法,在6只自主呼吸的麻醉犬身上进行了研究。在恒定麻醉水平下,通过向气道内插入金属珠造成气流阻塞后,犬出现高碳酸血症。通过活塞泵快速振荡包裹在下胸部的改良双血压袖带内的压力来实现高频胸壁按压。30分钟的自主通气期与30分钟的自主呼吸加3、5或8赫兹的高频胸壁按压期交替进行。高频胸壁按压叠加于自主通气时,动脉血氧分压(PaO2)变化不大。然而,在每种情况下,动脉血二氧化碳分压(PaCO2)均从平均值6.55±0.59千帕降至3赫兹时的4.72±0.32千帕(p<0.05)、5赫兹时的6.92±0.57千帕降至3.9±0.45千帕(p<0.01)以及8赫兹时的7.10±0.65千帕降至4.56±0.59千帕(p<0.05)。尽管自主分钟通气量有所下降,但仍出现了这种情况。我们得出结论,高频胸壁按压可帮助患有高碳酸血症的气道阻塞自主呼吸犬消除二氧化碳。