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[Demonstration of the O-demethylation reaction catalyzed by a peroxidase: application to 9-methoxyellipticine].

作者信息

Meunier G, Paoletti C, Meunier B

出版信息

C R Acad Sci III. 1984;299(15):629-32.

PMID:6440666
Abstract

9-methoxy ellipticine, an antitumor compound, is O-demethylated in presence of the system peroxidase-H2O2; this reaction yields the corresponding electrophilic quinone-imine and methanol. This O-demethylation reaction is reported for the first time and might be possibly extended to some other antitumor drugs.

摘要

相似文献

1
[Demonstration of the O-demethylation reaction catalyzed by a peroxidase: application to 9-methoxyellipticine].
C R Acad Sci III. 1984;299(15):629-32.
2
Peroxidase-catalyzed O-demethylation reactions. Quinone-imine formation from 9-methoxyellipticine derivatives.过氧化物酶催化的O-去甲基化反应。9-甲氧基玫瑰树碱衍生物形成醌亚胺。
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Peroxidase-catalysed oxidation of N2,N6-dimethyl-9-hydroxyellipticinium acetate. Evidence for the formation of an electrophilic quinone-iminium derivative.
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Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.过氧化物酶-过氧化氢体系对抗肿瘤药物9-羟基玫瑰树碱及其衍生物的生物活化作用。
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[Demonstration of an oxidative biotransformation of 9-methoxyellipticine. Comparison with the case of 9-hydroxyellipticine].
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