Takacs L, Osawa H, Diamantstein T
Eur J Immunol. 1984 Dec;14(12):1152-6. doi: 10.1002/eji.1830141217.
During embryonic development of the mouse, before expressing classical T cell markers, the blast cells colonizing the thymus react with the monoclonal antibody AMT-13 shown previously to detect interleukin 2 receptors. The proportion of AMT-13+ cells decreases as gestation time increases. On the other hand, the proportion of Thy-1+, Lyt-1+ and Lyt-2+ cells increases during ontogenesis. On the 19th day of gestation when the thymus architecture is comparable to the adult thymus, the AMT-13+ cells become localized in the subcapsular area of the cortex. In the adult thymus after cortison treatment the regenerating cells express the AMT-13 antigen. The AMT-13 antigen presumably the interleukin 2 receptor is the first marker of the early embryonic thymocytes reported until now that may be related to cellular function.
在小鼠胚胎发育过程中，在表达经典T细胞标志物之前，定位于胸腺的胚细胞可与先前用于检测白细胞介素2受体的单克隆抗体AMT-13发生反应。随着妊娠时间的增加，AMT-13+细胞的比例下降。另一方面，Thy-1+、Lyt-1+和Lyt-2+细胞的比例在个体发育过程中增加。在妊娠第19天，当胸腺结构与成年胸腺相似时，AMT-13+细胞定位于皮质的被膜下区域。在成年胸腺经皮质激素处理后，再生细胞表达AMT-13抗原。AMT-13抗原大概就是白细胞介素2受体，是迄今为止报道的早期胚胎胸腺细胞的首个可能与细胞功能相关的标志物。
